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Gamma-Glutamyl Transpeptidases

Structure and Function

Gamma-Glutamyl Transpeptidases( )
Author: Castellano, Immacolata
Merlino, Antonello
Series title:SpringerBriefs in Biochemistry and Molecular Biology Ser.
ISBN:978-3-0348-0681-7
Publication Date:Jul 2013
Publisher:Springer Basel AG
Imprint:Springer
Book Format:Paperback
List Price:USD $54.99
Book Description:

 Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical...
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