Transcription Factors and Human Disease |
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| Author:
| Semenza, Gregg L. |
| Series title: | Oxford Monographs on Medical Genetics Ser. |
| ISBN: | 978-0-19-511239-9 |
| Publication Date: | Aug 1998 |
| Publisher: | Oxford University Press, Incorporated
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| Book Format: | Hardback |
| List Price: | AUD $103.59AUD $146.95 |
Book Description:
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Transcription Factors and Human Disease presents the basic science of transcriptional regulation and the inherited human diseases attributable to mutations in DNA sequences encoding transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is discussed, as well as the effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessiveinheritance patterns, and disease...
More DescriptionTranscription Factors and Human Disease presents the basic science of transcriptional regulation and the inherited human diseases attributable to mutations in DNA sequences encoding transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is discussed, as well as the effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessiveinheritance patterns, and disease pathogenesis. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.