Advances in Medicinal Chemistry |
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| Editor:
| Maryanoff, Bruce E.
Maryanoff, Cynthia A. |
| Series title: | Advances in Medicinal Chemistry Ser. |
| ISBN: | 978-1-55938-581-7 |
| Publication Date: | Oct 1993 |
| Publisher: | Elsevier Science & Technology Books
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| Book Format: | Hardback |
| List Price: | AUD $220.00 |
Book Description:
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Volume 2 of Advances in Medicinal Chemistry is comprised of six chapters on diverse facets of medicinal chemistry. Chapter 1 deals mainly addresses enzymological considerations and the rational design of novel steroid-based 5aelig;-reductase inhibitors, one of which (SKF-105657)is undergoing clinical evaluation. Chapter 2 relates to the discovery, structural elucidation, anti-tumor activity and DNA cleavage properties of the calicheamicins. This continues in Chapter 3 where the...
More DescriptionVolume 2 of Advances in Medicinal Chemistry is comprised of six chapters on diverse facets of medicinal chemistry. Chapter 1 deals mainly addresses enzymological considerations and the rational design of novel steroid-based 5aelig;-reductase inhibitors, one of which (SKF-105657)is undergoing clinical evaluation. Chapter 2 relates to the discovery, structural elucidation, anti-tumor activity and DNA cleavage properties of the calicheamicins. This continues in Chapter 3 where the authors address CC-1065 as a potent anti-tumor antibiotic with an unusual structure. Chapter 4 gives an overview on the discovery at Merck of antagonists of cholecystokinin, a peptide hormone. In Chapter 5, an elaboration of a non-classic case of finding a nonpeptide small molecule for inhibition of a peptide receptor is given. Also addressed are the structure-activity relationships for a novel series of substituted imidazoles that antagonise the angiotensin II receptor. Finally, Chapter 6 chronicles the evolution of the aldose reductase inhibitor program at Pfizer, from sorbinil to zopolrestat.