Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity |
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| Series edited by:
| Fambrough, Douglas M. |
| Volume Editor:
| Benos, Dale J. |
| Series title: | Current Topics in Membranes Ser. |
| ISBN: | 978-0-12-089030-9 |
| Publication Date: | Oct 1999 |
| Publisher: | Elsevier Science & Technology Books
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| Book Format: | Paperback |
| List Price: | AUD $185.00 |
Book Description:
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Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels...
More DescriptionSodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.