Epstein-Barr Virus and Human Cancer

The Epstein-Barr Virus (EBV), discovered three decades ago as the first human cancer virus candidate, has long been known to be causally associated with Burkitt's lymphoma in equatorial Africa and with nasopharyngeal carcinoma in southern China. More recently, as molecular virology and immunology have developed, a wide variety of malignancies including B-cell, T-cell, and NK-cell lymphomas, Hodgkin's disease, thymic tumors, and gastric carcinoma, are becoming closely linked with this...
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The Epstein-Barr Virus (EBV), discovered three decades ago as the first human cancer virus candidate, has long been known to be causally associated with Burkitt's lymphoma in equatorial Africa and with nasopharyngeal carcinoma in southern China. More recently, as molecular virology and immunology have developed, a wide variety of malignancies including B-cell, T-cell, and NK-cell lymphomas, Hodgkin's disease, thymic tumors, and gastric carcinoma, are becoming closely linked with this particular virus. This volume covers molecular advances in EBV virology and oncology, a new role for EBV in gastric carcinogenesis, and evidence for EBV's etiologic role in a number of hematopoietic disorders. Consideration is also given to the detection of EBV in nonendemic nasopharyngeal carcinoma, the global epidemiology of EBV malignancies, and essential features of EBV infection and oncogenesis in terms of viral ubiquity and risk factors. Finally, a new therapeutic approach to EBV oncogenesis is discussed. Providing an excellent survey of current research on EBV's role in human cancers, this book is essential reading for basic and clinical scientists in virology, oncology and hematology.