Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological and Pathophysiological Effects Vol. 54 |
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| Volume Editor:
| Schwiebert, Erik Mills |
| Series title: | Current Topics in Membranes Ser. |
| ISBN: | 978-0-12-153354-0 |
| Publication Date: | Jun 2003 |
| Publisher: | Elsevier Science & Technology Books
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| Book Format: | Hardback |
| List Price: | AUD $324.00 |
Book Description:
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Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express...
More DescriptionPurinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors.