Hmg-Coa Reductase Inhibitors

HMG-CoA reductase inhibitors (statins) are established drugs for thetreatment of hypercholesterolemia. Furthermore, they induce regressionof vascular atherosclerosis as well as reduction ofcardiovascular-related morbidity and death in patients with and withoutcoronary artery disease. This book deals with statins which havesubstantially altered the approach to therapy of atherosclerosis and itssequelae. Emphasis is placed on the scientific background to thediscoveries and the...
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HMG-CoA reductase inhibitors (statins) are established drugs for thetreatment of hypercholesterolemia. Furthermore, they induce regressionof vascular atherosclerosis as well as reduction ofcardiovascular-related morbidity and death in patients with and withoutcoronary artery disease. This book deals with statins which havesubstantially altered the approach to therapy of atherosclerosis and itssequelae. Emphasis is placed on the scientific background to thediscoveries and the development of the therapy, including an overview ofthe current state of knowledge of the drugs. Clinical data are reviewedextensively. This book not only provides the reader with valuableinformation but also stimulates further research into the pathogenesisof atherosclerosis and the mechanisms behind the action of effectivestatins. It sets the stage for creative thinking among scientists ofmany disciplines for the accomplishment of our ultimate goals intreating atherosclerosis and its sequelae. This topical volume...