Phosphoinositide 3-Kinase Signalling Pathway

Aimed at advanced undergraduates, postgraduates and researchers, this important textbook provides a detailed description of the structure and mechanisms of phosphoinositide 3-kinase (PI3Ks) signalling of all classes, with focus on the cellular context of PI3K activity, including its relevance to normal tissue and diseased states. This book contains a general review chapter detailing the mechanisms of cell proliferation and apoptosis, which are two of the main cellular targets of PI3K...
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Aimed at advanced undergraduates, postgraduates and researchers, this important textbook provides a detailed description of the structure and mechanisms of phosphoinositide 3-kinase (PI3Ks) signalling of all classes, with focus on the cellular context of PI3K activity, including its relevance to normal tissue and diseased states. This book contains a general review chapter detailing the mechanisms of cell proliferation and apoptosis, which are two of the main cellular targets of PI3K signalling. In addition, it provides a detailed description of the role of PI3K on the regulation of FOXO proteins, which are now becoming one of the most closely studied and important proteins in the regulation of cell death, cell proliferation and senescence. Contents: Introduction (E W-F Lam); Cell Proliferation and Cell Death; In Vivo Roles of Cell Cycle and Apoptosis Regulators; The Role of Phosphoinositide 3-Kinase in Proliferation and Apoptosis (A Sunters & E W-F Lam); Phosphoinositide 3-Kinase Signalling Pathway; Class IA PI3K Enzymes; Class IB PI3K Enzymes; Class II PI3K Enzymes; Class III PI3K Enzymes; Expression of PI3K Enzymes; 3-Phosphoinositide Binding Domains; Downstream Targets of 3-Phosphoinositide; Manipulation of PI3K Enzyme Expression; Biological Role of PI3K Signalling Pathway; Phosphoinositide Phosphatases; The Role of the PI3K Pathway in Disease (J Domin); PI3K Signalling to Cell Survival and Proliferation; Molecules Directly Regulated by D3 Lipids; Genetic Studies of PI3K Function in Model Organisms; Molecules Downstream of PI3K and D3 Lipids; PI3K Regulation of Cell Survival; Signalling from PI3K to Cell Proliferation; Alterations of PI3K and Its Pathways in Cancer; Cancer Therapeutics (P Brennan); FOXO Transcription Factors; Forkhead Transcription Factors; FOXO Transcription Factors; Signalling to FOXO Proteins; Cellular Relocation Mechanism; FOXO Protein Processing; Transcriptional Activity of FoxO Proteins; Functions of FOXO in Vivo; FOXO Targets and Function; FOXO Proteins in Transformation and Diseases (S Fernandez de Mattos et al.). Key Features Provides a clear and well-organized review of PI3K signalling garnered from an exhaustive review of the available literature Readership: Undergraduates, postgraduates, academic researchers, clinicians and scientists working in industry.