Studies in Anaphylaxis and Immunity

Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: lesion to be one of the central nervous system laut it is now accepted that the lesion is a peripheral one. There is still considerable question as to whether it is a lesion of the nerve endings or other cells of the body. A nunber of workers have more or less definitely located the principal lesion in...
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Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: lesion to be one of the central nervous system laut it is now accepted that the lesion is a peripheral one. There is still considerable question as to whether it is a lesion of the nerve endings or other cells of the body. A nunber of workers have more or less definitely located the principal lesion in different animals. It must be borne in mind that the principal lesion differs in all animals thus far studdied. rchultz (11) has shown that the principal lesion of the acute anaphylactic shock in the guinea-pig is the contracticnlof the smooth muscle surrounding the larger branches of the bronchial tree. The animal dies an asphyixial death due to the fact tho.t no air can escape from the lungs. This is the most rapid death and the one that has been best explained. He has also shown that the lesion in white mice is, with the exception of the lung picture similar to th: t seen in guinea-pigs that almost die. Arthus (12) and Auer (13) have shown that the death in the rabbit is due to the failure of the heart itself due to the weakening of the heart muscle. Pearce and Eisenbrey (14) claim that the action in the dog is characterized by a sudden and presis- tent fall in blood pressure followed by objective syrcp- (11 12 (13 (14 Jr. Phar. and xp. Ther., ii, 1911. C. R. Soc. de Biol., Iv, 1903. Jr. of xp. ?.: ed.. xiv, lull. Jr. Inf. Lis., vii, 1910. toma referable to ?erebr? anemia. Schittenhelm (4) regards the heroorrhagic condition of the digestive tract as the nost important lesion. Pearce and Eisenbrey made similar observations but did not emphasize the lesion. ?'anwaring (15) clairs that the lesion in the dog is due to some action of the liver. Schultz (16) and Dale (3) have both worked upon smooth muscle tissue. Schultz found that smooth muscle from the guinea-pig's intes..