The Journal of Experimental Medicine

Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: A CASE OF PSEUDO-LUPUS VULGARIS CAUSED BY A BLASTOMYCES. By T. CASPAR GILCHEIST, M. R. C. S., And WILLIAM ROYAL STOKES, M. D., Baltimore. (From the Pathological Laboratory of the Johns Hopkins University and- Hospital.) Plates IV-VIII. Within the last three year? a number of important communications have...
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Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: A CASE OF PSEUDO-LUPUS VULGARIS CAUSED BY A BLASTOMYCES. By T. CASPAR GILCHEIST, M. R. C. S., And WILLIAM ROYAL STOKES, M. D., Baltimore. (From the Pathological Laboratory of the Johns Hopkins University and- Hospital.) Plates IV-VIII. Within the last three year? a number of important communications have appeared concerning pathogenic yeasts. Before this period it was generally believed that among the yeast plants there existed none pathogenic for man or animals. The experiments of Bernard, Grohe, Popoff, Falk, and the more recent ones of Neumayer and of Raum, furnished no satisfactory evidence in favor of the possession of infectious properties by the blastomycetes. In August, 1894, Busse published a brief report, followed in April, 1895, by a fuller account of a case interpreted by him as one of chronic pyaemia, in which he foiind in tissue removed during life and in diseased foci after death, numerous parasitic bodies which he proved to be yeast fungi. These he isolated in pure culture and inoculated successfully into animals. He designated the disease produced by this parasite in man as saccharomycosis hominis. In May, 1894, three months before Busse's first publication, one of us (Gilchrist) exhibited and described before the American Dermato- logical Association in Washington, microscopical sections from a case of cutaneous disease in Philadelphia under the care of Dr. Duhring, who had excised and sent a piece for microscopical examination. Peculiar parasitic bodies, which were interpreted as plant rather than animal forms, were observed and described. After the appearance of Busse's paper these bodies were recognized as forms of blastomycetes. This case has been fully described and illustrated by Gilchrist under the title of A Case of Blastomyceti...