Immunobiology of Bacterial CpG-DNA |
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| Editor:
| Wagner, H. |
| Series title: | Current Topics in Microbiology and Immunology Ser. |
| ISBN: | 978-3-642-59672-8 |
| Publication Date: | Dec 2012 |
| Publisher: | Springer
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| Book Format: | Ebook |
| List Price: | USD $149.00 |
Book Description:
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Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging...
More DescriptionBacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.