Mass Spectrometry in Biophysics |
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Author:
| Kaltashov, Igor A. Eyles, Stephen J. |
Series title: | Wiley-Interscience Series on Mass Spectrometry Ser. |
ISBN: | 978-1-280-27538-8 |
Publication Date: | Jan 2005 |
Publisher: | John Wiley & Sons Canada, Limited
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Imprint: | Wiley-Interscience |
Book Format: | Ebook |
List Price: | USD $132.00 |
Book Description:
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The first systematic summary of biophysical mass spectrometry techniques Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's acceptance of MS-based methods, used to study protein higher-order structure and dynamics, has accelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presented the full array of MS-based...
More DescriptionThe first systematic summary of biophysical mass spectrometry techniques
Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's acceptance of MS-based methods, used to study protein higher-order structure and dynamics, has accelerated the expansion of biophysical MS.
Despite this growing trend, until now no single text has presented the full array of MS-based experimental techniques and strategies for biophysics. Mass Spectrometry in Biophysics expertly closes this gap in the literature.
Covering the theoretical background and technical aspects of each method, this much-needed reference offers an unparalleled overview of the current state of biophysical MS. Mass Spectrometry in Biophysics begins with a helpful discussion of general biophysical concepts and MS-related techniques. Subsequent chapters address:
* Modern spectrometric hardware
* High-order structure and dynamics as probed by various MS-based methods
* Techniques used to study structure and behavior of non-native protein states that become populated under denaturing conditions
* Kinetic aspects of protein folding and enzyme catalysis
* MS-based methods used to extract quantitative information on protein-ligand interactions
* Relation of MS-based techniques to other experimental tools
* Biomolecular properties in the gas phase
Fully referenced and containing a helpful appendix on the physics of electrospray mass spectrometry, Mass Spectrometry in Biophysics also offers a compelling look at the current challenges facing biomolecular MS and the potential applications that will likely shape its future.