Polyploidization and Cancer |
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| Editor:
| Poon, Randy Y. |
| Series title: | Advances in Experimental Medicine and Biology Ser. |
| ISBN: | 978-1-283-07441-4 |
| Publication Date: | Jan 2010 |
| Publisher: | Springer
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| Book Format: | Ebook |
| List Price: | USD $249.00 |
Book Description:
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Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying...
More DescriptionLimiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.