Protein Quality Control in Neurodegenerative Diseases |
|
| Editor:
| Christen, Yves
Morimoto, Richard I. |
| Series title: | Research and Perspectives in Alzheimer's Disease Ser. |
| ISBN: | 978-3-642-27927-0 |
| Publication Date: | Dec 2012 |
| Publisher: | Springer Berlin / Heidelberg
|
| Imprint: | Springer |
| Book Format: | Hardback |
| List Price: | USD $169.99 |
Book Description:
|
The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease,...
More DescriptionThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.